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G protein-coupled receptors: structure- and function-based drug discovery.

ABSTRACT: As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace. This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery.

SUBMITTER: Yang D

PROVIDER: S-EPMC7790836 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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G protein-coupled receptors: structure- and function-based drug discovery.

Yang Dehua D Zhou Qingtong Q Labroska Viktorija V Qin Shanshan S Darbalaei Sanaz S Wu Yiran Y Yuliantie Elita E Xie Linshan L Tao Houchao H Cheng Jianjun J Liu Qing Q Zhao Suwen S Shui Wenqing W Jiang Yi Y Wang Ming-Wei MW

Signal transduction and targeted therapy 20210108 1

As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace. This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common ...[more]

PMID: 33414387

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