Ontology highlight
ABSTRACT:
SUBMITTER: Song L
PROVIDER: S-EPMC7791068 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Song Lin L Cao Lijuan L Liu Rui R Ma Hui H Li Yanan Y Shang Qianwen Q Zheng Zhiyuan Z Zhang Liying L Zhang Wen W Han Yuyi Y Zhang Xiaoren X Yang Huilin H Wang Ying Y Melino Gerry G Shao Changshun C Shi Yufang Y
Cell death & disease 20201214 1
Glucocorticoids (GC) are widely used clinically, despite the presence of significant side effects, including glucocorticoid-induced osteoporosis (GIOP). While GC are believed to act directly on osteoblasts and osteoclasts to promote osteoporosis, the detailed underlying molecular mechanism of GC-induced osteoporosis is still not fully elucidated. Here, we show that lymphocytes play a pivotal role in regulating GC-induced osteoporosis. We show that GIOP could not be induced in SCID mice that lack ...[more]