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TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii.


ABSTRACT: Apicomplexan parasites have evolved efficient and distinctive strategies for intracellular replication where the timing of emergence of the daughter cells (budding) is a decisive element. However, the molecular mechanisms that provide the proper timing of parasite budding remain unknown. Using Toxoplasma gondii as a model Apicomplexan, we identified a master regulator that controls the timing of the budding process. We show that an ApiAP2 transcription factor, TgAP2IX-5, controls cell cycle events downstream of centrosome duplication. TgAP2IX-5 binds to the promoter of hundreds of genes and controls the activation of the budding-specific cell cycle expression program. TgAP2IX-5 regulates the expression of specific transcription factors that are necessary for the completion of the budding cycle. Moreover, TgAP2IX-5 acts as a limiting factor that ensures that asexual proliferation continues by promoting the inhibition of the differentiation pathway. Therefore, TgAP2IX-5 is a master regulator that controls both cell cycle and developmental pathways.

SUBMITTER: Khelifa AS 

PROVIDER: S-EPMC7791101 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii.

Khelifa Asma S AS   Guillen Sanchez Cecilia C   Lesage Kevin M KM   Huot Ludovic L   Mouveaux Thomas T   Pericard Pierre P   Barois Nicolas N   Touzet Helene H   Marot Guillemette G   Roger Emmanuel E   Gissot Mathieu M  

Nature communications 20210107 1


Apicomplexan parasites have evolved efficient and distinctive strategies for intracellular replication where the timing of emergence of the daughter cells (budding) is a decisive element. However, the molecular mechanisms that provide the proper timing of parasite budding remain unknown. Using Toxoplasma gondii as a model Apicomplexan, we identified a master regulator that controls the timing of the budding process. We show that an ApiAP2 transcription factor, TgAP2IX-5, controls cell cycle even  ...[more]

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