Ontology highlight
ABSTRACT:
SUBMITTER: Park S
PROVIDER: S-EPMC7791112 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Cell death discovery 20210106 1
Among the three isoforms encoded by Rtn4, Nogo-A has been intensely investigated as a central nervous system inhibitor. Although Nogo-A expression is increased in muscles of patients with amyotrophic lateral sclerosis, its role in muscle homeostasis and regeneration is not well elucidated. In this study, we discovered a significant increase in Nogo-A expression in various muscle-related pathological conditions. Nogo<sup>-/-</sup> mice displayed dystrophic muscle structure, dysregulated muscle re ...[more]