Phenome-wide and genome-wide analyses of quality of life in schizophrenia.

ABSTRACT:

Background

Schizophrenia negatively affects quality of life (QoL). A handful of variables from small studies have been reported to influence QoL in patients with schizophrenia, but a study comprehensively dissecting the genetic and non-genetic contributing factors to QoL in these patients is currently lacking.

Aims

We adopted a hypothesis-generating approach to assess the phenotypic and genotypic determinants of QoL in schizophrenia.

Method

The study population comprised 1119 patients with a psychotic disorder, 1979 relatives and 586 healthy controls. Using linear regression, we tested >100 independent demographic, cognitive and clinical phenotypes for their association with QoL in patients. We then performed genome-wide association analyses of QoL and examined the as

SUBMITTER: Pazoki R 

PROVIDER: S-EPMC7791571 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature