Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020.

ABSTRACT: Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion ?69/?70, circulating mainly between early September and mid-November, was 10% (6-13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion ?69/?70, circulating since late September, was 75% (70-80%) more transmissible than the 501N lineage.

SUBMITTER: Leung K 

PROVIDER: S-EPMC7791602 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature