Dataset Information

Efficacy of stem cells therapy for Crohn's fistula: a meta-analysis and systematic review.

ABSTRACT:

Background

Fistulas have puzzled us all the time and stem cell therapy for it is still in its infancy. We conducted a meta-analysis and systematic review to evaluate the efficacy of stem cells and its potential mechanisms in the management of Crohn's fistula.

Methods

Electronic databases were searched comprehensively for studies reporting the efficacy and safety of stem cells in patients with any form of Crohn's fistula. A random-effects model was used, and all outcomes were calculated by SPSS 24.0.

Results

Twenty-nine articles with 1252 patients were included. It showed that stem cell group had a higher rate of fistula healing compared to placebo group in patients of Crohn's fistula (61.75% vs 40.46%, OR 2.21, 95% CI 1.19 to 4.11, P?7 cells/mL stem cell (SC) group had an advantage in fistula healing rate with 71.0% compared to other doses group of stem cells (RR 1.3, 95% CI 0.76 to 2.22). And the healing rates of patients with perianal and transsphincteric fistulas (77.95%, 76.41%) were higher than those with rectovaginal fistulas. It was an amazing phenomenon that CDAI and PDAI scores occurred an obviously transient rise with the use of stem cells after 1?month (both of P?ConclusionsOur study has highlighted that stem cells was a promising method in the treatment of Crohn's fistula based on its higher efficacy and lower incidence of adverse events, especially ADSCs and Cx601. While it also needs more clinical and pre-clinical studies to strengthen evidences in the future.

SUBMITTER: Cao Y

PROVIDER: S-EPMC7792029 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Efficacy of stem cells therapy for Crohn's fistula: a meta-analysis and systematic review.

Cao Yantian Y Su Qi Q Zhang Bangjie B Shen Fangfang F Li Shaoshan S

Stem cell research & therapy 20210107 1

<h4>Background</h4>Fistulas have puzzled us all the time and stem cell therapy for it is still in its infancy. We conducted a meta-analysis and systematic review to evaluate the efficacy of stem cells and its potential mechanisms in the management of Crohn's fistula.<h4>Methods</h4>Electronic databases were searched comprehensively for studies reporting the efficacy and safety of stem cells in patients with any form of Crohn's fistula. A random-effects model was used, and all outcomes were calcu ...[more]

PMID: 33413661

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Dataset Information

Efficacy of stem cells therapy for Crohn's fistula: a meta-analysis and systematic review.

Background

Methods

Results

Publications

Efficacy of stem cells therapy for Crohn's fistula: a meta-analysis and systematic review.

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