Ontology highlight
ABSTRACT: Background
Atrial fibrillation (AF) is a common arrhythmia, which is closely related to cardiovascular morbidity and mortality. Although acupuncture is used in the treatment of AF, the evidence is insufficient. The objective of this pilot trial is to evaluate the feasibility, preliminary efficacy, and safety of acupuncture in reducing AF burden for persistent AF after catheter ablation (CA).Methods and design
This will be a multi-center, 3-arm, pilot randomized controlled trial in China. Sixty patients in total will be randomly assigned to the specific acupoints group, the non-specific acupoints group, or the non-acupoints group in a 1:1:1 ratio. The whole study period is 6?months, including a 3-month treatment period and a 3-month follow-up period. All patients will receive 18 sessions of acupuncture over 12?weeks after CA and appropriate post-ablation routine treatment. The primary outcome is AF burden at 6?months after CA measured by electrocardiography patch that can carry out a 7-day continuous ambulatory electrocardiographic monitoring. The secondary outcomes include AF burden at 3 ?months after CA, recurrence of AF, quality of life, etc. The adverse events will also be recorded.Discussion
This pilot study will contribute to evaluating the feasibility, preliminary efficacy, and safety of acupuncture in reducing AF burden for persistent AF after CA. The results will be used for the sample size calculation of a subsequent large-scale trial.Trial registration
Chinese Clinical Trial Registry ChiCTR2000030576 . Registered on 7 March 2020.
SUBMITTER: Lin Y
PROVIDER: S-EPMC7792186 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Lin Ying Y Wang Xian X Li Xue-Bin XB Wu Bang-Qi BQ Zhang Zhao-Hui ZH Guo Wei-Hua WH Wu Cun-Cao CC Chen Xin X Chen Ming-Long ML Dai Zhong Z Chen Fu-Yan FY Zhu Rui R Liang Chu-Xi CX Tian Yun-Peng YP Yang Gang G Yan Chao-Qun CQ Lu Jing J Wang Hai-Ying HY Li Jin-Ling JL Tu Jian-Feng JF Li He-Wen HW Yang Dan-Dan DD Yu Fang-Ting FT Wang Yu Y Yang Jing-Wen JW Shi Guang-Xia GX Yan Shi-Yan SY Wang Li-Qiong LQ Liu Cun-Zhi CZ
Trials 20210107 1
<h4>Background</h4>Atrial fibrillation (AF) is a common arrhythmia, which is closely related to cardiovascular morbidity and mortality. Although acupuncture is used in the treatment of AF, the evidence is insufficient. The objective of this pilot trial is to evaluate the feasibility, preliminary efficacy, and safety of acupuncture in reducing AF burden for persistent AF after catheter ablation (CA).<h4>Methods and design</h4>This will be a multi-center, 3-arm, pilot randomized controlled trial i ...[more]