Dataset Information

Long non-coding RNA FAM83H-AS1 acts as a potential oncogenic driver in human ovarian cancer.

ABSTRACT:

Objective

Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) is demonstrated play an important roles in a many cancers, the detailed function and mechanism has not been reported in OC.

Results

We integrated multiple kinds of bioinformatics approaches and experiments validated method to evaluate functions of FAM83H-AS1 in OC. Some differential expressed lncRNAs were identified between OC and normal control tissues. FAM83H-AS1 was one of most differentially expressed lncRNAs and up-regulated in multiple cancer types. Specially, expression of FAM83H-AS1 was higher in OC and showed difference in diverse stages. High FAM83H-AS1 expression is associated with worse pan-cancer and OC outcomes. FAM83H-AS1-centric network including lncRNA-miRNA, lncRNA-protein and lncRNA-mRNA ceRNA network were constructed to infer the function and mechanism of FAM83H-AS1. There were two methylation sites including cg01399317 and cg20519035 located at FAM83H-AS1. The methylation level of cg01399317 was correlated with gene expression of FAM83H-AS1. The expression level of FAM83H-AS1 was correlated with infiltration level of immune cell including macrophage, neutrphil and dendritic cell in OC patients. Lastly, qRT-PCR showed that the expression of FAM83H-AS1 was higher in OC tissues than normal control tissues.

Conclusion

Collectively, these results indicated that FAM83H-AS1 may act as an oncogenic driver and it may be a potential therapy target in OC.

SUBMITTER: Yuan X

PROVIDER: S-EPMC7792319 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Long non-coding RNA FAM83H-AS1 acts as a potential oncogenic driver in human ovarian cancer.

Yuan Xiaolei X Huang Ying Y Guo Man M Hu Xiaowei X Li Peiling P

Journal of ovarian research 20210107 1

<h4>Objective</h4>Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. Long non-coding RNAs (lncRNAs) could as major players in OC process. Although FAM83H antisense RNA1 (FAM83H-AS1) is demonstrated play an important roles in a many cancers, the detailed function and mechanism has not been reported in OC.<h4>Results</h4>We integrated multiple kinds of bioinformatics approaches and experiments validated method to evaluate functi ...[more]

PMID: 33413565

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Dataset Information

Long non-coding RNA FAM83H-AS1 acts as a potential oncogenic driver in human ovarian cancer.

Objective

Results

Conclusion

Publications

Long non-coding RNA FAM83H-AS1 acts as a potential oncogenic driver in human ovarian cancer.

Similar Datasets

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