Ontology highlight
ABSTRACT:
SUBMITTER: Norheim F
PROVIDER: S-EPMC7792507 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Molecular systems biology 20210101 1
To elucidate the contributions of specific lipid species to metabolic traits, we integrated global hepatic lipid data with other omics measures and genetic data from a cohort of about 100 diverse inbred strains of mice fed a high-fat/high-sucrose diet for 8 weeks. Association mapping, correlation, structure analyses, and network modeling revealed pathways and genes underlying these interactions. In particular, our studies lead to the identification of Ifi203 and Map2k6 as regulators of hepatic p ...[more]