Dataset Information

Nonesterified Fatty Acids and Depression in Cancer Patients and Caregivers.

ABSTRACT:

Background

Nonesterified fatty acids (NEFAs) are known to have inflammatory effects. The inflammatory hypothesis of depression suggests that omega-3 (?-3) and omega-6 (?-6) fatty acids might be negatively and positively correlated with depression, respectively.

Objective

An exploratory study was conducted to determine the association between dietary free fatty acids and depressive symptoms in cancer patients and caregivers.

Methods

Associations between depression and the NEFA pool were investigated in 56 cancer patients and 23 caregivers using a combination of nonparametric tests and regularized regression. Plasma NEFAs were measured using thin layer and gas chromatography with flame ionization detection. Depression was characterized both as a continuous severity score using the GRID-Hamilton Depression Rating Scale (GRID Ham-D), and as a categorical diagnosis of major depression by structured clinical interview.

Results

Initial hypotheses regarding the relation between depression and omega-3 or omega-6 fatty acids were not well supported. However, elaidic acid, a trans-unsaturated fatty acid found in hydrogenated vegetable oils, was found to be negatively correlated with continuous depression scores in cancer patients. No significant associations were found in caregivers.

Conclusions

An unexpected negative association between elaidic acid and depression was identified, supporting recent literature on the role of G protein-coupled receptors in depression. Further research is needed to confirm this result and to evaluate the potential role of G protein agonists as therapeutic agents for depression in cancer patients.

SUBMITTER: McCusker MR

PROVIDER: S-EPMC7792569 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Nonesterified Fatty Acids and Depression in Cancer Patients and Caregivers.

McCusker Megan R MR Bazinet Richard P RP Metherel Adam H AH Klein Roberta Yael RY Kundra Arjun A Haibe-Kains Benjamin B Li Madeline M

Current developments in nutrition 20201013 11

<h4>Background</h4>Nonesterified fatty acids (NEFAs) are known to have inflammatory effects. The inflammatory hypothesis of depression suggests that omega-3 (ω-3) and omega-6 (ω-6) fatty acids might be negatively and positively correlated with depression, respectively.<h4>Objective</h4>An exploratory study was conducted to determine the association between dietary free fatty acids and depressive symptoms in cancer patients and caregivers.<h4>Methods</h4>Associations between depression and the NE ...[more]

PMID: 33447694

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Project description:Background and objectivesAlthough nonesterified fatty acids (NEFAs) are essential as energy substrate for the myocardium, an excess of circulating NEFAs can be harmful. This study aimed to assess plausible relationships between serum NEFA and mortality due to cardiovascular disease (CVD) in individuals with CKD.Design, setting, participants, & measurementsThis was a prospective cohort study from the third examination cycle of the Uppsala Longitudinal Study of Adult Men, a population-based survey of 1221 elderly men aged 70-71 years residing in Uppsala, Sweden. Data collection took place during 1991-1995. All participants had measures of kidney function; this study investigated 623 (51.7%) of these patients with manifest CKD (defined as either eGFR<60 ml/min per 1.73 m(2) or urine albumin excretion rate ≥20 µg/min). Follow-up for mortality was done from examination date until death or December 31, 2007. After a median follow-up of 14 years (interquartile range, 8-16.8), associations of NEFAs with mortality (related to all causes, CVD, ischemic heart disease [IHD], or acute myocardial infarction) were ascertained.ResultsThe median serum NEFA was 14.1 mg/dl (interquartile range, 11.3-17.8). No association was found with measures of kidney function. Diabetes and serum triglycerides were the only multivariate correlates of NEFA. During follow-up, 453 participants died, of which 209 deaths were due to CVD, including 88 IHD deaths, with 41 attributed to acute myocardial infarction (AMI). In fully adjusted covariates, serum NEFA was an independent risk factor for all-cause mortality (hazard ratio [HR] per log2 increase, 1.22; 95% confidence interval [95% CI], 1.00 to 1.48) and CVD-related death (HR, 1.51; 95% CI, 1.15 to 1.99), including both IHD (HR, 1.51; 95% CI, 1.00 to 2.32) and AMI mortality (HR, 2.08; 95% CI, 1.09 to 3.98).ConclusionsElevated serum NEFA associated with CVD mortality, and particularly with mortality due to AMI, in a homogeneous population of older men with moderate CKD.

Dataset Information

Nonesterified Fatty Acids and Depression in Cancer Patients and Caregivers.

Background

Objective

Methods

Results

Conclusions

Publications

Nonesterified Fatty Acids and Depression in Cancer Patients and Caregivers.

Similar Datasets

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