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E-cigarette, or Vaping, Product Use-Associated Lung Injury: Looking Back, Moving Forward.

ABSTRACT: Implications In this commentary, we describe the evidence-based approach used to identify the primary cause of EVALI and to curb the 2019 outbreak. We also discuss future research opportunities and public health practice considerations to prevent a resurgence of EVALI.

SUBMITTER: King BA

PROVIDER: S-EPMC7792918 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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E-cigarette, or Vaping, Product Use-Associated Lung Injury: Looking Back, Moving Forward.

King Brian A BA Jones Christopher M CM Baldwin Grant T GT Briss Peter A PA

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20201201 Suppl 1

Implications In this commentary, we describe the evidence-based approach used to identify the primary cause of EVALI and to curb the 2019 outbreak. We also discuss future research opportunities and public health practice considerations to prevent a resurgence of EVALI. ...[more]

PMID: 33320257

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Project description:BackgroundE-cigarette or vaping has become an increasingly popular alternative to smoking tobacco. In September 2019 multiple cases of confirmed E-cigarette or vaping product use associated lung injury were published. However, there is limited knowledge regarding the pathologic mechanism of this condition.MethodsWe performed a systematic literature review in PubMed and EMBASE aiming to obtain additional clinical data on confirmed E-cigarette or vaping product use associated lung injury cases with lung biopsy results. With this information we hope to determine whether this condition is related to a histopathological pattern of acute lung injury instead of lipid deposits.ResultsSeven articles were reviewed and a total of 27 cases were included. Imaging findings predominantly showed presence of diffuse bilateral ground glass opacities. A majority of patients had complete resolution of the disease. The most common histopathological pattern was organizing pneumonia present in almost half of the patients. Other frequently occurring patterns included diffuse alveolar damage and acute fibrinous pneumonitis; lipoid pneumonia was found in one case.ConclusionThe underlying pathophysiological mechanism in E-cigarette or vaping product use associated lung injury is most likely acute lung injury related to direct inhalant-mediated parenchymal inflammation.

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