Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC7793260 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Liu Xiaolong X Biboy Jacob J Consoli Elisa E Vollmer Waldemar W den Blaauwen Tanneke T
PLoS genetics 20201228 12
Rod-shape of most bacteria is maintained by the elongasome, which mediates the synthesis and insertion of peptidoglycan into the cylindrical part of the cell wall. The elongasome contains several essential proteins, such as RodA, PBP2, and the MreBCD proteins, but how its activities are regulated remains poorly understood. Using E. coli as a model system, we investigated the interactions between core elongasome proteins in vivo. Our results show that PBP2 and RodA form a complex mediated by thei ...[more]