Evaluating the association of single-nucleotide polymorphisms with tenofovir exposure in a diverse prospective cohort of women living with HIV.
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ABSTRACT:
SUBMITTER: Baxi SM
PROVIDER: S-EPMC7793629 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Evaluating the association of single-nucleotide polymorphisms with tenofovir exposure in a diverse prospective cohort of women living with HIV.
Baxi S M SM Greenblatt R M RM Bacchetti P P Cohen M M DeHovitz J A JA DeHovitz J A JA Anastos K K Gange S J SJ Young M A MA Aouizerat B E BE
The pharmacogenomics journal 20170502 2
Higher exposure to tenofovir (TFV) increases the risk for kidney function decline, but the impact of genetic factors on TFV exposure is largely unknown. We investigated whether single-nucleotide polymorphisms (SNPs, n=211) in 12 genes are potentially involved in TFV exposure. Participants (n=91) from the Women's Interagency HIV Study, underwent a 24 h intensive pharmacokinetic sampling of TFV after witnessed dose and TFV area under the time-concentration curves (AUCs) were calculated for each pa ...[more]
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