Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction.
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ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC7793928 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction.
Sun Jie J Qiao Yan-Ning YN Tao Tao T Zhao Wei W Wei Li-Sha LS Li Ye-Qiong YQ Wang Wei W Wang Ye Y Zhou Yu-Wei YW Zheng Yan-Yan YY Chen Xin X Pan Hong-Chun HC Zhang Xue-Na XN Zhu Min-Sheng MS
Frontiers in physiology 20201203
Both smooth muscle (SM) and non-muscle (NM) myosin II are expressed in hollow organs such as the bladder and uterus, but their respective roles in contraction and corresponding physiological functions remain to be determined. In this report, we assessed their roles by analyzing mice deficient of <i>Myl9</i>, a gene encoding the SM myosin regulatory light chain (SM RLC). We find that global <i>Myl9</i>-deficient bladders contracted with an apparent sustained phase, despite no initial phase. This ...[more]
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