Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC7794093 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Liu Chao C Yang Cangjie C Hwang Seung S Ferraro Samantha L SL Flynn James P JP Niu Jia J
Angewandte Chemie (International ed. in English) 20200820 42
O-sulfation is an important chemical code widely existing in bioactive molecules, but the scalable and facile synthesis of complex bioactive molecules carrying O-sulfates remains challenging. Reported here is a general approach to O-sulfation by the sulfur(VI) fluoride exchange (SuFEx) reaction between aryl fluorosulfates and silylated hydroxy groups. Efficient sulfate diester formation was achieved through systematic optimization of the electronic properties of aryl fluorosulfates. The versatil ...[more]