Dataset Information

Lymph node response to chemoradiotherapy in oesophageal cancer patients: relationship with radiotherapy fields.

ABSTRACT:

Background

The presence of lymph node metastasis (LNmets) is a poor prognostic factor in oesophageal cancer (OeC) patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgery. Tumour regression grade (TRG) in LNmets has been suggested as a predictor for survival. The aim of this study was to investigate whether TRG in LNmets is related to their location within the radiotherapy (RT) field.

Methods

Histopathological TRG was retrospectively classified in 2565 lymph nodes (LNs) from 117 OeC patients treated with nCRT and surgery as: (A) no tumour, no signs of regression; (B) tumour without regression; (C) viable tumour and regression; and (D) complete response. Multivariate survival analysis was used to investigate the relationship between LN location within the RT field, pathological TRG of the LN and TRG of the primary tumour.

Results

In 63 (54%) patients, viable tumour cells or signs of regression were seen in 264 (10.2%) LNs which were classified as TRG-B (n?=?56), C (n?=?104) or D (n?=?104) LNs. 73% of B, C and D LNs were located within the RT field. There was a trend towards a relationship between LN response and anatomical LN location with respect to the RT field (p?=?0.052). Multivariate analysis showed that only the presence of LNmets within the RT field with TRG-B is related to poor overall survival.

Conclusion

Patients have the best survival if all LNmets show tumour regression, even if LNmets are located outside the RT field. Response in LNmets to nCRT is heterogeneous which warrants further studies to better understand underlying mechanisms.

SUBMITTER: Koemans WJ

PROVIDER: S-EPMC7794105 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Lymph node response to chemoradiotherapy in oesophageal cancer patients: relationship with radiotherapy fields.

Koemans Willem J WJ Larue Ruben T H M RTHM Kloft Maximilian M Ruisch Jessica E JE Compter Inge I Riedl Robert G RG Heij Lara R LR van Elmpt Wouter W Berbée Maaike M Buijsen Jeroen J Lambin Philippe P Sosef Meindert N MN Grabsch Heike I HI

Esophagus : official journal of the Japan Esophageal Society 20200905 1

<h4>Background</h4>The presence of lymph node metastasis (LNmets) is a poor prognostic factor in oesophageal cancer (OeC) patients treated with neoadjuvant chemoradiotherapy (nCRT) followed by surgery. Tumour regression grade (TRG) in LNmets has been suggested as a predictor for survival. The aim of this study was to investigate whether TRG in LNmets is related to their location within the radiotherapy (RT) field.<h4>Methods</h4>Histopathological TRG was retrospectively classified in 2565 lymph ...[more]

PMID: 32889674

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Dataset Information

Lymph node response to chemoradiotherapy in oesophageal cancer patients: relationship with radiotherapy fields.

Background

Methods

Results

Conclusion

Publications

Lymph node response to chemoradiotherapy in oesophageal cancer patients: relationship with radiotherapy fields.

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