Ontology highlight
ABSTRACT:
SUBMITTER: Song X
PROVIDER: S-EPMC7794242 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210108 1
Coronaviruses spike (S) glycoproteins mediate viral entry into host cells by binding to host receptors. However, how the S1 subunit undergoes conformational changes for receptor recognition has not been elucidated in Alphacoronavirus. Here, we report the cryo-EM structures of the HCoV-229E S trimer in prefusion state with two conformations. The activated conformation may pose the potential exposure of the S1-RBDs by decreasing of the interaction area between the S1-RBDs and the surrounding S1-NT ...[more]