Ontology highlight
ABSTRACT:
SUBMITTER: Geis M
PROVIDER: S-EPMC7794243 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Geis Maria M Nowotny Boris B Bohn Marc-Dominic MD Kouhestani Dina D Einsele Hermann H Bumm Thomas T Stuhler Gernot G
Communications biology 20210108 1
Bispecific T cell engaging antibodies (BiTEs) address tumor associated antigens that are over-expressed on cancer but that can also be found on healthy tissues, causing substantial on-target/off-tumor toxicities. To overcome this hurdle, we recently introduced hemibodies, a pair of complementary antibody fragments that redirect T cells against cancer-defining antigen combinations. Here we show that hemibodies addressing CD38 and SLAMF7 recruit T cells for the exquisite elimination of dual antige ...[more]