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Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram.


ABSTRACT: Accurate prediction of peritoneal metastasis for gastric cancer (GC) with serosal invasion is crucial in clinic. The presence of collagen in the tumour microenvironment affects the metastasis of cancer cells. Herein, we propose a collagen signature, which is composed of multiple collagen features in the tumour microenvironment of the serosa derived from multiphoton imaging, to describe the extent of collagen alterations. We find that a high collagen signature is significantly associated with a high risk of peritoneal metastasis (P?

SUBMITTER: Chen D 

PROVIDER: S-EPMC7794254 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram.

Chen Dexin D   Liu Zhangyuanzhu Z   Liu Wenju W   Fu Meiting M   Jiang Wei W   Xu Shuoyu S   Wang Guangxing G   Chen Feng F   Lu Jianping J   Chen Hao H   Dong Xiaoyu X   Li Guoxin G   Chen Gang G   Zhuo Shuangmu S   Yan Jun J  

Nature communications 20210108 1


Accurate prediction of peritoneal metastasis for gastric cancer (GC) with serosal invasion is crucial in clinic. The presence of collagen in the tumour microenvironment affects the metastasis of cancer cells. Herein, we propose a collagen signature, which is composed of multiple collagen features in the tumour microenvironment of the serosa derived from multiphoton imaging, to describe the extent of collagen alterations. We find that a high collagen signature is significantly associated with a h  ...[more]

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