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Comparing microfluidics and ultrasonication as formulation methods for developing hempseed oil nanoemulsions for oral delivery applications.


ABSTRACT: Emerging formulation technologies aimed to produce nanoemulsions with improved characteristics, such as stability are attractive endeavors; however, comparisons between competing technologies are lacking. In this study, two formulation techniques that employed ultrasound and microfluidic approaches, respectively, were examined for relative capacity to produce serviceable oil in water nanoemulsions, based on hempseed oil (HSO). The ultrasound method reached?>?99.5% entrapment efficiency with nanoemulsions that had an average droplet size (Z-Ave)?

SUBMITTER: Fathordoobady F 

PROVIDER: S-EPMC7794282 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Comparing microfluidics and ultrasonication as formulation methods for developing hempseed oil nanoemulsions for oral delivery applications.

Fathordoobady Farahnaz F   Sannikova Natalia N   Guo Yigong Y   Singh Anika A   Kitts David D DD   Pratap-Singh Anubhav A  

Scientific reports 20210108 1


Emerging formulation technologies aimed to produce nanoemulsions with improved characteristics, such as stability are attractive endeavors; however, comparisons between competing technologies are lacking. In this study, two formulation techniques that employed ultrasound and microfluidic approaches, respectively, were examined for relative capacity to produce serviceable oil in water nanoemulsions, based on hempseed oil (HSO). The ultrasound method reached > 99.5% entrapment efficiency with nano  ...[more]

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