Ontology highlight
ABSTRACT:
SUBMITTER: Stojakovic A
PROVIDER: S-EPMC7794523 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Stojakovic Andrea A Trushin Sergey S Sheu Anthony A Khalili Layla L Chang Su-Youne SY Li Xing X Christensen Trace T Salisbury Jeffrey L JL Geroux Rachel E RE Gateno Benjamin B Flannery Padraig J PJ Dehankar Mrunal M Funk Cory C CC Wilkins Jordan J Stepanova Anna A O'Hagan Tara T Galkin Alexander A Nesbitt Jarred J Zhu Xiujuan X Tripathi Utkarsh U Macura Slobodan S Tchkonia Tamar T Pirtskhalava Tamar T Kirkland James L JL Kudgus Rachel A RA Schoon Renee A RA Reid Joel M JM Yamazaki Yu Y Kanekiyo Takahisa T Zhang Song S Nemutlu Emirhan E Dzeja Petras P Jaspersen Adam A Kwon Ye In Christopher YIC Lee Michael K MK Trushina Eugenia E
Communications biology 20210108 1
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial inhibition of complex I triggers the AMP-activated protein kinase-dependent signaling network leading to neuroprotection in symptomatic APP/PS1 female mice, a translational model of AD. Treatment of symptomatic APP/PS1 mice with complex I inhibitor improved energy homeostasis, synaptic activ ...[more]