Ontology highlight
ABSTRACT:
SUBMITTER: Choi KE
PROVIDER: S-EPMC7794530 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20210108 1
We aimed to develop an outer retinal degeneration pig model induced by temporary intravitreal loading of N-methyl-N-nitrosourea (MNU) during vitrectomy. In a preliminary experiment involving 5 mini-pig cases to determine the appropriate concentration of MNU, the vitreous cavity of each eye was filled with 4, 8, 10, 12, or 16 mg/mL MNU for 10 min, which was then replaced with a balanced salt solution. Multimodal examinations including spectral-domain optical coherence tomography (OCT) images and ...[more]