Ontology highlight
ABSTRACT:
SUBMITTER: Nie X
PROVIDER: S-EPMC7794601 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nie Xiu X Qian Liujia L Sun Rui R Huang Bo B Dong Xiaochuan X Xiao Qi Q Zhang Qiushi Q Lu Tian T Yue Liang L Chen Shuo S Li Xiang X Sun Yaoting Y Li Lu L Xu Luang L Li Yan Y Yang Ming M Xue Zhangzhi Z Liang Shuang S Ding Xuan X Yuan Chunhui C Peng Li L Liu Wei W Yi Xiao X Lyu Mengge M Xiao Guixiang G Xu Xia X Ge Weigang W He Jiale J Fan Jun J Wu Junhua J Luo Meng M Chang Xiaona X Pan Huaxiong H Cai Xue X Zhou Junjie J Yu Jing J Gao Huanhuan H Xie Mingxing M Wang Sihua S Ruan Guan G Chen Hao H Su Hua H Mei Heng H Luo Danju D Zhao Dashi D Xu Fei F Li Yan Y Zhu Yi Y Xia Jiahong J Hu Yu Y Guo Tiannan T
Cell 20210109 3
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report a proteomic analysis of 144 autopsy samples from seven organs in 19 COVID-19 patients. We quantified 11,394 proteins in these samples, in which 5,336 were perturbed in the COVID-19 patients compared to controls. Our data showed that cathepsin L1, rather than ACE2, was significantly upregulated in the lung from the COVID-19 patients. Systemic hyperin ...[more]