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ABSTRACT:
SUBMITTER: Lambruschini C
PROVIDER: S-EPMC7794914 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Lambruschini Chiara C Demori Ilaria I El Rashed Zeinab Z Rovegno Leila L Canessa Elena E Cortese Katia K Grasselli Elena E Moni Lisa L
Molecules (Basel, Switzerland) 20201228 1
The Ugi four-component reaction employing naturally occurred ferulic acid (FA) is proposed as a convenient method to synthesize feruloyl tertiary amides. Applying this strategy, a peptoid-like derivative of ferulic acid (FEF77) containing 2 additional hydroxy-substituted aryl groups, has been synthesized. The influence of the configuration of the double bond of ferulic acid and feruloyl amide on the antioxidant activity has been investigated thanks to light-mediated isomerization studies. At the ...[more]