Dataset Information

Light Scattering and Rheological Studies of 3D/4D Printable Shape Memory Gels Based on Poly (N,N-Dimethylacrylamide-co-Stearyl Acrylate and/or Lauryl Acrylates).

ABSTRACT: In this work, we present the structural analysis of 3D/4D printable N,N-dimethylacrylamide (DMAAm)-co-stearyl acrylate (SA) and/or lauryl acrylate (LA)-based shape memory gels (SMGs). We characterized these gels by scanning microscopic light scattering technique (SMILS) where a time- and space-averaged correlation function is obtained to overcome the inhomogeneous media. Thus, the characteristic size of the gel internal network (mesh size, ?) and crosslinking densities are estimated from the Einstein-Stokes formula. The rheological study of the SMGs revealed information about their mechanical strength and transition temperature. From the experimental storage modulus measured by rheological study, crosslinking density and mesh size of the network were also calculated. Both the techniques suggest that SMG with high crystalline content of SA monomer in the gel network contain smaller mesh size (1.13 nm for SMILS and 9.5 nm for rheology study) and high crosslinking density. The comparative study between the light scattering technique and rheological analysis through the quantitative analysis of crosslinking densities will be important to understand the structural properties of the SMGs.

SUBMITTER: Shiblee MDNI

PROVIDER: S-EPMC7794971 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Light Scattering and Rheological Studies of 3D/4D Printable Shape Memory Gels Based on Poly (N,N-Dimethylacrylamide-co-Stearyl Acrylate and/or Lauryl Acrylates).

Shiblee M D Nahin Islam MDNI Ahmed Kumkum K Yamazaki Yuta Y Kawakami Masaru M Furukawa Hidemitsu H

Polymers 20201230 1

In this work, we present the structural analysis of 3D/4D printable N,N-dimethylacrylamide (DMAAm)-co-stearyl acrylate (SA) and/or lauryl acrylate (LA)-based shape memory gels (SMGs). We characterized these gels by scanning microscopic light scattering technique (SMILS) where a time- and space-averaged correlation function is obtained to overcome the inhomogeneous media. Thus, the characteristic size of the gel internal network (mesh size, ξ) and crosslinking densities are estimate ...[more]

PMID: 33396902

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Project description:Reactive oxygen species (ROS) play a key role in several biological functions like regulating cell survival and signaling; however, their effect can range from beneficial to nondesirable oxidative stress when they are overproduced causing inflammation or cancer diseases. Thus, the design of tailor-made ROS-responsive polymers offers the possibility of engineering hydrogels for target therapies. In this work, we developed thioether-based ROS-responsive difunctional monomers from ethylene glycol/thioether acrylate (EGnSA) with different lengths of the EGn chain (n = 1, 2, 3) by the thiol-Michael addition click reaction. The presence of acrylate groups allowed their photopolymerization by UV light, while the thioether groups conferred ROS-responsive properties. As a result, smart PEGnSA hydrogels were obtained, which could be processed by four-dimensional (4D) printing. The mechanical properties of the hydrogels were determined by rheology, pointing out a decrease of the elastic modulus (G') with the length of the EG segment. To enhance the stability of the hydrogels after swelling, the EGnSA monomers were copolymerized with a polar monomer, 2-hydroxyethyl acrylate (HEA), leading to P[(EGnSA)x-co-HEAy] with improved compatibility in aqueous media, making it a less brittle material. Swelling properties of the hydrogels increased in the presence of hydrogen peroxide, a kind of ROS, reaching values of ≈130% for P[(EG3SA)7-co-HEA93] which confirms the stimuli-responsive properties. Then, the P[(EG3SA)x-co-HEAy] hydrogels were employed as matrixes for the encapsulation of a chemotherapeutic drug, 5-fluorouracil (5FU), which showed sustained release over time modulated by the presence of H2O2. Finally, the effect of the 5-FU release from P[(EG3SA)x-co-HEAy] hydrogels was tested in vitro with melanoma cancer cells B16F10, pointing out B16F10 growth inhibition values in the range of 40-60% modulated by the EG3SA percentage and the presence or absence of ROS agents, thus confirming their excellent ROS-responsive properties for the treatment of localized pathologies.

Dataset Information

Light Scattering and Rheological Studies of 3D/4D Printable Shape Memory Gels Based on Poly (N,N-Dimethylacrylamide-co-Stearyl Acrylate and/or Lauryl Acrylates).

Publications

Light Scattering and Rheological Studies of 3D/4D Printable Shape Memory Gels Based on Poly (<i>N</i>,<i>N</i>-Dimethylacrylamide-co-Stearyl Acrylate and/or Lauryl Acrylates).

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