Ontology highlight
ABSTRACT:
SUBMITTER: Chubarov A
PROVIDER: S-EPMC7795135 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Chubarov Alexey A Spitsyna Anna A Krumkacheva Olesya O Mitin Dmitry D Suvorov Daniil D Tormyshev Victor V Fedin Matvey M Bowman Michael K MK Bagryanskaya Elena E
Molecules (Basel, Switzerland) 20201229 1
Pulsed Dipolar Spectroscopy (PDS) methods of Electron Paramagnetic Resonance (EPR) were used to detect and characterize reversible non-covalent dimers of Human Serum Albumin (HSA), the most abundant protein in human plasma. The spin labels, MTSL and OX063, were attached to Cys-34 and these chemical modifications of Cys-34 did affect the dimerization of HSA, indicating that other post-translational modifications can modulate dimer formation. At physiologically relevant concentrations, HSA does fo ...[more]