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The Interfacial Interactions of Glycine and Short Glycine Peptides in Model Membrane Systems.


ABSTRACT: The interactions of amino acids and peptides at model membrane interfaces have considerable implications for biological functions, with the ability to act as chemical messengers, hormones, neurotransmitters, and even as antibiotics and anticancer agents. In this study, glycine and the short glycine peptides diglycine, triglycine, and tetraglycine are studied with regards to their interactions at the model membrane interface of Aerosol-OT (AOT) reverse micelles via 1H NMR spectroscopy, dynamic light scattering (DLS), and Langmuir trough measurements. It was found that with the exception of monomeric glycine, the peptides prefer to associate between the interface and bulk water pool of the reverse micelle. Monomeric glycine, however, resides with the N-terminus in the ordered interstitial water (stern layer) and the C-terminus located in the bulk water pool of the reverse micelle.

SUBMITTER: Doucette KA 

PROVIDER: S-EPMC7795424 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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The Interfacial Interactions of Glycine and Short Glycine Peptides in Model Membrane Systems.

Doucette Kaitlin A KA   Chaiyasit Prangthong P   Calkins Donn L DL   Martinez Kayli N KN   Van Cleave Cameron C   Knebel Callan A CA   Tongraar Anan A   Crans Debbie C DC  

International journal of molecular sciences 20201226 1


The interactions of amino acids and peptides at model membrane interfaces have considerable implications for biological functions, with the ability to act as chemical messengers, hormones, neurotransmitters, and even as antibiotics and anticancer agents. In this study, glycine and the short glycine peptides diglycine, triglycine, and tetraglycine are studied with regards to their interactions at the model membrane interface of Aerosol-OT (AOT) reverse micelles via <sup>1</sup>H NMR spectroscopy,  ...[more]

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