Ontology highlight
ABSTRACT:
SUBMITTER: Nelson C
PROVIDER: S-EPMC7795613 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nelson Corey C Mrozowich Tyler T Gemmill Darren L DL Park Sean M SM Patel Trushar R TR
International journal of molecular sciences 20210102 1
Flavivirus genus includes many deadly viruses such as the Japanese encephalitis virus (JEV) and Zika virus (ZIKV). The 5' terminal regions (TR) of flaviviruses interact with human proteins and such interactions are critical for viral replication. One of the human proteins identified to interact with the 5' TR of JEV is the DEAD-box helicase, DDX3X. In this study, we in vitro transcribed the 5' TR of JEV and demonstrated its direct interaction with recombinant DDX3X (K<sub>d</sub> of 1.66 ± 0.21 ...[more]