Ontology highlight
ABSTRACT:
SUBMITTER: Rami A
PROVIDER: S-EPMC7795642 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Rami Avina A Łaczmański Łukasz Ł Jacków-Nowicka Jagoda J Jacków Joanna J Jacków Joanna J
International journal of molecular sciences 20201229 1
The early onset and rapid progression of cutaneous squamous cell carcinoma (cSCC) leads to high mortality rates in individuals with recessive dystrophic epidermolysis bullosa (RDEB). Currently, the molecular mechanisms underlying cSCC development in RDEB are not well understood and there are limited therapeutic options. RDEB-cSCC arises through the accumulation of genetic mutations; however, previous work analyzing gene expression profiles have not been able to explain its aggressive nature. The ...[more]