Ontology highlight
ABSTRACT:
SUBMITTER: Yeom DH
PROVIDER: S-EPMC7796106 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Yeom Dong-Hoon DH Lee Yo-Seob YS Ryu Ilhwan I Lee Sunju S Sung Byungje B Lee Han-Byul HB Kim Dongin D Ahn Jin-Hyung JH Ha Eunsin E Choi Yong-Soo YS Lee Sang Hoon SH You Weon-Kyoo WK
International journal of molecular sciences 20201229 1
Delta-like-ligand 4 (DLL4) is a promising target to augment the effects of VEGF inhibitors. A simultaneous blockade of VEGF/VEGFR and DLL4/Notch signaling pathways leads to more potent anti-cancer effects by synergistic anti-angiogenic mechanisms in xenograft models. A bispecific antibody targeting VEGF and DLL4 (ABL001/NOV1501/TR009) demonstrates more potent in vitro and in vivo biological activity compared to VEGF or DLL4 targeting monoclonal antibodies alone and is currently being evaluated i ...[more]