Ontology highlight
ABSTRACT:
SUBMITTER: Duerr M
PROVIDER: S-EPMC7796396 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Duerr Michael M Liefeldt Lutz L Friedersdorff Frank F Choi Mira M Öllinger Robert R Hofmann Jörg J Budde Klemens K Schrezenmeier Eva E Halleck Fabian F
Journal of clinical medicine 20201229 1
Transplant candidates are facing incremental mortality risks on the waiting list. Here, we report a novel strategy to expand the donor pool by including hepatitis C seropositive (HCV+) donors. We investigated a pre-exposure prophylactic (PrEP) treatment with direct-acting antivirals (DAA) to allow transplantation for HCV seronegative (HCV-) kidney transplant recipients (KTR) with the aim to prevent HCV infection post transplantation. In this prospective trial, a pan-genotypic PrEP with daclatasv ...[more]