Ontology highlight
ABSTRACT:
SUBMITTER: Pape VFS
PROVIDER: S-EPMC7796460 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Pape Veronika F S VFS Gaál Anikó A Szatmári István I Kucsma Nóra N Szoboszlai Norbert N Streli Christina C Fülöp Ferenc F Enyedy Éva A ÉA Szakács Gergely G
Cancers 20210105 1
Resistance to chemotherapeutic agents is a major obstacle in cancer treatment. A recently proposed strategy is to target the collateral sensitivity of multidrug resistant (MDR) cancer. Paradoxically, the toxicity of certain metal chelating agents is increased, rather than decreased, by the function of P-glycoprotein (Pgp), which is known to confer resistance by effluxing chemotherapeutic compounds from cancer cells. We have recently characterized and compared the solution's chemical properties i ...[more]