Dataset Information

Assessing genomic diversity and signatures of selection in Jiaxian Red cattle using whole-genome sequencing data.

ABSTRACT:

Background

Native cattle breeds are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and tough feeding conditions. Jiaxian Red, a Chinese native cattle breed, is reported to have originated from crossbreeding between taurine and indicine cattle; their history as a draft and meat animal dates back at least 30?years. Using whole-genome sequencing (WGS) data of 30 animals from the core breeding farm, we investigated the genetic diversity, population structure and genomic regions under selection of Jiaxian Red cattle. Furthermore, we used 131 published genomes of world-wide cattle to characterize the genomic variation of Jiaxian Red cattle.

Results

The population structure analysis revealed that Jiaxian Red cattle harboured the ancestry with East Asian taurine (0.493), Chinese indicine (0.379), European taurine (0.095) and Indian indicine (0.033). Three methods (nucleotide diversity, linkage disequilibrium decay and runs of homozygosity) implied the relatively high genomic diversity in Jiaxian Red cattle. We used ??, CLR, F_ST and XP-EHH methods to look for the candidate signatures of positive selection in Jiaxian Red cattle. A total number of 171 (?? and CLR) and 17 (F_ST and XP-EHH) shared genes were identified using different detection strategies. Functional annotation analysis revealed that these genes are potentially responsible for growth and feed efficiency (CCSER1), meat quality traits (ROCK2, PPP1R12A, CYB5R4, EYA3, PHACTR1), fertility (RFX4, SRD5A2) and immune system response (SLAMF1, CD84 and SLAMF6).

Conclusion

We provide a comprehensive overview of sequence variations in Jiaxian Red cattle genomes. Selection signatures were detected in genomic regions that are possibly related to economically important traits in Jiaxian Red cattle. We observed a high level of genomic diversity and low inbreeding in Jiaxian Red cattle. These results provide a basis for further resource protection and breeding improvement of this breed.

SUBMITTER: Xia X

PROVIDER: S-EPMC7796570 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Assessing genomic diversity and signatures of selection in Jiaxian Red cattle using whole-genome sequencing data.

Xia Xiaoting X Zhang Shunjin S Zhang Huaju H Zhang Zijing Z Chen Ningbo N Li Zhigang Z Sun Hongxia H Liu Xian X Lyu Shijie S Wang Xianwei X Li Zhiming Z Yang Peng P Xu Jiawei J Ding Xiaoting X Shi Qiaoting Q Wang Eryao E Ru Baorui B Xu Zejun Z Lei Chuzhao C Chen Hong H Huang Yongzhen Y

BMC genomics 20210109 1

<h4>Background</h4>Native cattle breeds are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and tough feeding conditions. Jiaxian Red, a Chinese native cattle breed, is reported to have originated from crossbreeding between taurine and indicine cattle; their history as a draft and meat animal dates back at least 30 years. Using whole-genome sequencing (WGS) data of 30 animals from the core breeding farm, we investigated the ...[more]

PMID: 33421990

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Dataset Information

Assessing genomic diversity and signatures of selection in Jiaxian Red cattle using whole-genome sequencing data.

Background

Results

Conclusion

Publications

Assessing genomic diversity and signatures of selection in Jiaxian Red cattle using whole-genome sequencing data.

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