Impact of IL-10 Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate.

ABSTRACT:

Background/aim

Prognosis of advanced stages of laryngeal squamous cell carcinoma (LSCC) remains poor. To clarify therapeutic targets and improve survival rate, identification of new specific and prognostic biomarkers of LSCC is required. The study aimed to evaluate the impact of IL-10:rs1800871, rs1800872, rs1800896 single nucleotide polymorphisms (SNPs), and IL-10 serum levels on LSCC development and determine associations of selected SNPs with patient survival rate.

Patients and methods

A total of 300 LSCC patients and 533 controls were included in the study. Genotyping was carried out using RT-PCR; IL-10 serum levels were analyzed by ELISA.

Results

Significant associations were identified between IL-10 rs1800871 variants and advanced stage of LSCC patient group in

SUBMITTER: Pasvenskaite A 

PROVIDER: S-EPMC7796822 | biostudies-literature | 2021 Jan-Feb

REPOSITORIES: biostudies-literature