Ontology highlight
ABSTRACT:
SUBMITTER: He S
PROVIDER: S-EPMC7797002 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
He Shanyang S He Shanyang S Wang Wei W Wan Zhiyong Z Shen Hongwei H Zhao Yunhe Y You Zeshan Z Liu Jun J Zhu Liwen L
Oncogenesis 20210109 1
Cisplatin resistance is frequently occurred in ovarian cancer therapy, understanding its regulatory mechanisms is critical for developing novel treatment methods and drugs. Here, we found ovarian cancer patients with low FAM83B levels had shorter survival time, tissues with cisplatin resistance also had low FAM83B levels, suggesting FAM83B might inhibit cisplatin resistance. FAM83B overexpression inhibits cisplatin resistance showed in increased ovarian cancer cell proliferation and growth rate, ...[more]