Ontology highlight
ABSTRACT:
SUBMITTER: Kang HJ
PROVIDER: S-EPMC7797050 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Kang Hyun Je HJ Cheon Na Young NY Park Hyun H Jeong Gyu Won GW Ye Byeong Jin BJ Yoo Eun Jin EJ Lee Jun Ho JH Hur Jin-Hoe JH Lee Eun-A EA Kim Hongtae H Lee Kyoo-Young KY Choi Soo Youn SY Lee-Kwon Whaseon W Myung Kyungjae K Lee Ja Yil JY Kwon Hyug Moo HM
Nucleic acids research 20210101 1
R-loops are three-stranded, RNA-DNA hybrid, nucleic acid structures produced due to inappropriate processing of newly transcribed RNA or transcription-replication collision (TRC). Although R-loops are important for many cellular processes, their accumulation causes genomic instability and malignant diseases, so these structures are tightly regulated. It was recently reported that R-loop accumulation is resolved by methyltransferase-like 3 (METTL3)-mediated m6A RNA methylation under physiological ...[more]