Dataset Information

HIV sexual transmission risk among serodiscordant couples: assessing the effects of combining prevention strategies.

ABSTRACT:

Background

The number of strategies to prevent HIV transmission has increased following trials evaluating antiretroviral therapy (ART), preexposure prophylaxis (PrEP) and male circumcision. Serodiscordant couples need guidance on the effects of these strategies alone, and in combination with each other, on HIV transmission.

Methods

We estimated the sexual risk of HIV transmission over 1-year and 10-year periods among male-male and male-female serodiscordant couples. We assumed the following reductions in transmission: 80% from consistent condom use; 54% from circumcision in the negative male partner of a heterosexual couple; 73% from circumcision in the negative partner of a male-male couple; 71% from PrEP in heterosexual couples; 44% from PrEP in male-male couples; and 96% from ART use by the HIV-infected partner.

Findings

For couples using any single prevention strategy, a substantial cumulative risk of HIV transmission remained. For a male-female couple using only condoms, estimated risk over 10 years was 11%; for a male-male couple using only condoms, estimated risk was 76%. ART use by the HIV-infected partner was the most effective single strategy in reducing risk; among male-male couples, adding consistent condom use was necessary to keep the 10-year risk below 10%.

Conclusion

Focusing on 1-year and longer term transmission probabilities gives couples a better understanding of risk than those illustrated by data for a single sexual act. Long-term transmission probabilities to the negative partner in serodiscordant couples can be high, though these can be substantially reduced with the strategic use of preventive methods, especially those that include ART.

SUBMITTER: Lasry A

PROVIDER: S-EPMC7797164 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Publications

HIV sexual transmission risk among serodiscordant couples: assessing the effects of combining prevention strategies.

Lasry Arielle A Sansom Stephanie L SL Wolitski Richard J RJ Green Timothy A TA Borkowf Craig B CB Patel Pragna P Mermin Jonathan J

AIDS (London, England) 20140601 10

<h4>Background</h4>The number of strategies to prevent HIV transmission has increased following trials evaluating antiretroviral therapy (ART), preexposure prophylaxis (PrEP) and male circumcision. Serodiscordant couples need guidance on the effects of these strategies alone, and in combination with each other, on HIV transmission.<h4>Methods</h4>We estimated the sexual risk of HIV transmission over 1-year and 10-year periods among male-male and male-female serodiscordant couples. We assumed the ...[more]

PMID: 24804859

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Dataset Information

HIV sexual transmission risk among serodiscordant couples: assessing the effects of combining prevention strategies.

Background

Methods

Findings

Conclusion

Publications

HIV sexual transmission risk among serodiscordant couples: assessing the effects of combining prevention strategies.

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