HLA Class I Binding of Mutant EGFR Peptides in NSCLC Is Associated With Improved Survival.

ABSTRACT:

Introduction

Cancer-associated mutations have the potential to generate neoantigens and elicit CD8-positive T-cell-dependent adaptive immune responses. There are currently no reports of CD8-positive T-cells with specificity for neoepitopes generated by EGFR mutations, which are driver oncogenes in a subset of patients with lung cancer.

Methods

We used NETMHCpan 4.0 to identify putative protective human leukocyte antigen (HLA) class I allotypes that are predicted in silico to bind and present mutant EGFR-generated peptides on the basis of predefined criteria. We associated the presence or absence of these alleles with clinical outcomes in patients from The Cancer Genome Atlas with lung adenocarcinoma.

Results

We identified 12 HLA class I alleles that fulfilled the pred

SUBMITTER: Dimou A 

PROVIDER: S-EPMC7797166 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature