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Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial.


ABSTRACT:

Background

Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.

Methods

We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.

Results

The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing.

Conclusions

GMA shows effectiveness in inducing remission in UC patients not receiving steroid.

SUBMITTER: Kakimoto K 

PROVIDER: S-EPMC7797742 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Exploratory Study of the Effectiveness of Granulocyte and Monocyte Adsorptive Apheresis Before Initiation of Steroids in Patients With Active Ulcerative Colitis (EXPECT Study): A Multicenter Prospective Clinical Trial.

Kakimoto Kazuki K   Matsuura Minoru M   Fukuchi Takumi T   Hongo Hitoshi H   Kimura Tsuguhiro T   Aoyama Nobuo N   Okuda Yorihide Y   Aomatsu Kazuki K   Kamata Noriko N   Yokoyama Yoko Y   Mizuno Chiemi C   Inoue Takuya T   Miyazaki Takako T   Nakamura Shiro S   Higuchi Kazuhide K   Nakase Hiroshi H  

Crohn's & colitis 360 20200923 4


<h4>Background</h4>Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.<h4>Methods</h4>We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.<h4>Results</h4>The response rate of  ...[more]

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