Ontology highlight
ABSTRACT: Background
Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.Methods
We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.Results
The response rate of all patients was 58.2% (39/67). Of the 39 patients who achieved a response, 74.4% achieved endoscopically confirmed mucosal healing.Conclusions
GMA shows effectiveness in inducing remission in UC patients not receiving steroid.
SUBMITTER: Kakimoto K
PROVIDER: S-EPMC7797742 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Kakimoto Kazuki K Matsuura Minoru M Fukuchi Takumi T Hongo Hitoshi H Kimura Tsuguhiro T Aoyama Nobuo N Okuda Yorihide Y Aomatsu Kazuki K Kamata Noriko N Yokoyama Yoko Y Mizuno Chiemi C Inoue Takuya T Miyazaki Takako T Nakamura Shiro S Higuchi Kazuhide K Nakase Hiroshi H
Crohn's & colitis 360 20200923 4
<h4>Background</h4>Granulocyte and monocyte adsorptive apheresis (GMA) has been used for therapy of steroid-dependent/refractory ulcerative colitis (UC). The aim of this study was to investigate the effectiveness of GMA in UC patients not receiving steroids.<h4>Methods</h4>We conducted a single-arm, open-label, and multicenter prospective clinical trial. UC patients who had insufficient responses to 5-aminosalicylic acid received GMA twice a week for 5 weeks.<h4>Results</h4>The response rate of ...[more]