Associations Between Genetically Predicted Protein Levels and COVID-19 Severity.
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ABSTRACT:
SUBMITTER: Zhu J
PROVIDER: S-EPMC7797748 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Associations Between Genetically Predicted Protein Levels and COVID-19 Severity.
Zhu Jingjing J Wu Chong C Wu Lang L
The Journal of infectious diseases 20210101 1
It is critical to identify potential causal targets for SARS-CoV-2, which may guide drug repurposing options. We assessed the associations between genetically predicted protein levels and COVID-19 severity. Leveraging data from the COVID-19 Host Genetics Initiative comparing 6492 hospitalized COVID-19 patients and 1 012 809 controls, we identified 18 proteins with genetically predicted levels to be associated with COVID-19 severity at a false discovery rate of <0.05, including 12 that showed an ...[more]
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