Is COPD associated with increased risk for microaspiration in intubated critically ill patients?

ABSTRACT:

Background

Although COPD patients are at higher risk for aspiration when breathing spontaneously, no information is available on the risk for microaspiration in invasively ventilated COPD patients. The aim of our study was to determine the relationship between COPD and abundant microaspiration in intubated critically ill patients.

Methods

This was a retrospective analysis of prospectively collected data, provided by 3 randomized controlled trials on microaspiration in critically ill patients receiving invasive mechanical ventilation for more than 48 h. Abundant microaspiration was defined as the presence of pepsin and or alpha-amylase at significant levels in tracheal aspirates. In all study patients, pepsin and alpha-amylase were quantitatively measured in all tracheal aspi

SUBMITTER: Degroote T 

PROVIDER: S-EPMC7798009 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature