Circulating Levels of Calcitonin Gene-Related Peptide Are Lower in COVID-19 Patients.

ABSTRACT:

Background

To better understand the biology of COVID-19, we have explored the behavior of calcitonin gene-related peptide (CGRP), an angiogenic, vasodilating, and immune modulating peptide, in severe acute respiratory syndrome coronavirus 2 positive patients.

Methods

Levels of CGRP in the serum of 57 COVID-19 patients (24 asymptomatic, 23 hospitalized in the general ward, and 10 admitted to the intensive care unit) and healthy donors (n = 24) were measured by enzyme-linked immunosorbent assay (ELISA). In addition, to better understand the physiological consequences of the observed variations, we investigated by immunofluorescence the distribution of receptor activity modifying protein 1 (RAMP1), one of the components of the CGRP receptor, in autopsy lung specimens.

Result

SUBMITTER: Ochoa-Callejero L 

PROVIDER: S-EPMC7798995 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature