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CorGAT: a tool for the functional annotation of SARS-CoV-2 genomes.


ABSTRACT:

Summary

While over 150 thousand genomic sequences are currently available through dedicated repositories, ad hoc methods for the functional annotation of SARS-CoV-2 genomes do not harness all currently available resources for the annotation of functionally relevant genomic sites. Here we present CorGAT, a novel tool for the functional annotation of SARS-CoV-2 genomic variants. By comparisons with other state of the art methods we demonstrate that, by providing a more comprehensive and rich annotation, our method can facilitate the identification of evolutionary patterns in the genome of SARS-CoV-2.

Availability

Galaxy: http://corgat.cloud.ba.infn.it/galaxy; software: https://github.com/matteo14c/CorGAT/tree/Revision_V1; docker: https://hub.docker.com/r/laniakeacloud/galaxy_corgat.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Chiara M 

PROVIDER: S-EPMC7799324 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

CorGAT: a tool for the functional annotation of SARS-CoV-2 genomes.

Chiara Matteo M   Zambelli Federico F   Tangaro Marco Antonio MA   Mandreoli Pietro P   Horner David S DS   Pesole Graziano G  

Bioinformatics (Oxford, England) 20210401 22-23


<h4>Summary</h4>While over 200 000 genomic sequences are currently available through dedicated repositories, ad hoc methods for the functional annotation of SARS-CoV-2 genomes do not harness all currently available resources for the annotation of functionally relevant genomic sites. Here, we present CorGAT, a novel tool for the functional annotation of SARS-CoV-2 genomic variants. By comparisons with other state of the art methods we demonstrate that, by providing a more comprehensive and rich a  ...[more]

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