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ABSTRACT: Summary
While over 150 thousand genomic sequences are currently available through dedicated repositories, ad hoc methods for the functional annotation of SARS-CoV-2 genomes do not harness all currently available resources for the annotation of functionally relevant genomic sites. Here we present CorGAT, a novel tool for the functional annotation of SARS-CoV-2 genomic variants. By comparisons with other state of the art methods we demonstrate that, by providing a more comprehensive and rich annotation, our method can facilitate the identification of evolutionary patterns in the genome of SARS-CoV-2.Availability
Galaxy: http://corgat.cloud.ba.infn.it/galaxy; software: https://github.com/matteo14c/CorGAT/tree/Revision_V1; docker: https://hub.docker.com/r/laniakeacloud/galaxy_corgat.Supplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Chiara M
PROVIDER: S-EPMC7799324 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Chiara Matteo M Zambelli Federico F Tangaro Marco Antonio MA Mandreoli Pietro P Horner David S DS Pesole Graziano G
Bioinformatics (Oxford, England) 20210401 22-23
<h4>Summary</h4>While over 200 000 genomic sequences are currently available through dedicated repositories, ad hoc methods for the functional annotation of SARS-CoV-2 genomes do not harness all currently available resources for the annotation of functionally relevant genomic sites. Here, we present CorGAT, a novel tool for the functional annotation of SARS-CoV-2 genomic variants. By comparisons with other state of the art methods we demonstrate that, by providing a more comprehensive and rich a ...[more]