Ontology highlight
ABSTRACT:
SUBMITTER: Lee BS
PROVIDER: S-EPMC7799364 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Lee Bei Shi BS Hards Kiel K Engelhart Curtis A CA Hasenoehrl Erik J EJ Kalia Nitin P NP Mackenzie Jared S JS Sviriaeva Ekaterina E Chong Shi Min Sherilyn SMS Manimekalai Malathy Sony S MSS Koh Vanessa H VH Chan John J Xu Jiayong J Alonso Sylvie S Miller Marvin J MJ Steyn Adrie J C AJC Grüber Gerhard G Schnappinger Dirk D Berney Michael M Cook Gregory M GM Moraski Garrett C GC Pethe Kevin K
EMBO molecular medicine 20201207 1
The approval of bedaquiline has placed energy metabolism in the limelight as an attractive target space for tuberculosis antibiotic development. While bedaquiline inhibits the mycobacterial F<sub>1</sub> F<sub>0</sub> ATP synthase, small molecules targeting other components of the oxidative phosphorylation pathway have been identified. Of particular interest is Telacebec (Q203), a phase 2 drug candidate inhibitor of the cytochrome bcc:aa<sub>3</sub> terminal oxidase. A functional redundancy betw ...[more]