Ontology highlight
ABSTRACT:
SUBMITTER: Ancora M
PROVIDER: S-EPMC7800564 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Mitochondrial DNA. Part B, Resources 20170817 2
Mitochondrial DNA (mtDNA) plays a key role in the development of a competent oocyte. Mutations of the mitochondrial genome lead to an altered energetic metabolism with negative effects on oocyte developmental competence. In this study, mtDNA heteroplasmy at an intra-oocyte level and between the different analyzed human oocytes (<i>n</i> = 12) was identified by a next-generation sequencing (NGS) protocol previously developed by this research group and submitted to GenBank. This method highlighted ...[more]