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ABSTRACT: Background
This study examined whether an innate systemic inflammatory response (SIR) measured by combination neutrophil to lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS) was associated with overall survival (OS) in patients with esophagogastric cancer (EC) undergoing neoadjuvant chemotherapy (NAC) followed by surgery.Methods
Patients diagnosed with EC, managed with NAC prior to surgery at a regional referral center, between January 2010 and December 2015, were included. The mGPS and NLR were calculated within 12 weeks before NAC. Patients were grouped by combined NLR/mGPS score into three groups of increasing SIR: NLR???3 (n?=?152), NLR?>?3?+?mGPS?=?0 (n?=?55), and NLR?>?3?+?mGPS?>?0 (n?=?32). Univariable and multivariable Cox regression was used to analyse OS.Results
Overall, 337 NAC patients were included, with 301 (89%) proceeding to surgery and 215 (64%) having R0 resection. There were 203 deaths, with a median follow-up of those alive at censor of 69 months (range 44-114). Higher combined NLR/mGPS score (n?=?239) was associated with poorer OS independent of clinical stage and performance status (hazard ratio 1.28, 95% confidence interval 1.02-1.61; p?=?0.032), higher rate of progression on NAC (7% vs. 7% vs. 19%; p?=?0.003), and lower proportion of eventual resection (80% vs. 84% vs. 53%; p?=?0.003).Conclusions
The combined NLR/mGPS score was associated with OS and initial treatment outcomes in patients undergoing NAC prior to surgery for EC, stratifying survival in addition to clinical staging and performance status. The host SIR may be a useful adjunct to multidisciplinary decision making.
SUBMITTER: McSorley ST
PROVIDER: S-EPMC7801291 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
McSorley Stephen T ST Lau Hiu Y N HYN McIntosh David D Forshaw Matthew J MJ McMillan Donald C DC Crumley Andrew B AB
Annals of surgical oncology 20200905 2
<h4>Background</h4>This study examined whether an innate systemic inflammatory response (SIR) measured by combination neutrophil to lymphocyte ratio (NLR) and modified Glasgow Prognostic Score (mGPS) was associated with overall survival (OS) in patients with esophagogastric cancer (EC) undergoing neoadjuvant chemotherapy (NAC) followed by surgery.<h4>Methods</h4>Patients diagnosed with EC, managed with NAC prior to surgery at a regional referral center, between January 2010 and December 2015, we ...[more]