Ontology highlight
ABSTRACT:
SUBMITTER: Levine JA
PROVIDER: S-EPMC7801442 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20210111 1
Plasminogen activator inhibitor 1 (PAI-1) is a functional biomarker of the metabolic syndrome. Previous studies have demonstrated that PAI-1 is a mechanistic contributor to several elements of the syndrome, including obesity, hypertension and insulin resistance. Here we show that PAI-1 is also a critical regulator of hepatic lipid metabolism. RNA sequencing revealed that PAI-1 directly regulates the transcriptional expression of numerous genes involved in mammalian lipid homeostasis, including P ...[more]