Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation.
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ABSTRACT:
SUBMITTER: Kono Y
PROVIDER: S-EPMC7801483 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation.
Kono Yuta Y Colley Thomas T To Masako M Papaioannou Andriana I AI Mercado Nicolas N Baker Jonathan R JR To Yasuo Y Abe Shinji S Haruki Kosuke K Ito Kazuhiro K Barnes Peter J PJ
Scientific reports 20210111 1
Cigarette smoke impairs autophagy, an intracellular protein degradation system, but the consequences of this defect have not been fully elucidated, especially in macrophages. Dysfunctional alveolar macrophages play an important role in chronic obstructive pulmonary disease (COPD). Here we show that galectin-8, a danger receptor that identifies damaged intracellular host vesicles and initiates autophagosome engulfment, is elevated due to activation of autophagy by cigarette smoke extract (CSE) in ...[more]
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