Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling.
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ABSTRACT:
SUBMITTER: Ma Q
PROVIDER: S-EPMC7801485 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling.
Ma Qinyu Q Liang Mengmeng M Wu Yutong Y Luo Fei F Ma Zaisong Z Dong Shiwu S Xu Jianzhong J Dou Ce C
Bone research 20210111 1
Bone remodeling is precisely coordinated by bone resorption and formation. Apoptotic osteoclasts generate large amounts of apoptotic bodies (ABs) marking the end of the bone resorption phase, whereas the functions of osteoclast-derived ABs remain largely unknown. Here, we identified the molecular profile of ABs derived from osteoclasts at distinct differentiation stages and investigated their corresponding functions. ABs were isolated from apoptotic bone marrow macrophages, preosteoclasts, and m ...[more]
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